Protein Details: Inward rectifier potassium channel 16

Protein ID

ICDB_Pro_0605

Protein Name

Inward rectifier potassium channel 16

Gene Name

Kcnj16

Organism

Rattus norvegicus (Rat)

Length

419 amino acids

AlphaFoldDB

AF-P52191-F1-model_v4.pdb

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised; the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance (By similarity). In the kidney; together with KCNJ10; mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules

Sequence

MSYYGSSYRIVNVDSKYPGYPPEHAIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYMVDIFTTLVDTKWRHMFVVFSLSYILSWLIFGSIFWLIALHHGDLLSDPDITPCVDNVHSFTAAFLFSLETQTTIGYGYRCVTEECSVAVLTVILQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYSEDSEGRMTMAFKDLKLVNDQIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYVPREILWGHRFHDVLEVKRKYYKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLNNLEKTSPARGSCTSDTNTRRRSFSAVAMVSSCENPEETSLSPQDECKEVPYQKALLTLNRISMESQM

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in the brain; testis; liver; spleen; kidney; submaxillary gland and adrenals. In the kidney; expressed in the epithelial cells of both proximal and distal convoluted tubules; in the endothelial cells surrounding glomerular capillaries and in the flattened parietal layer of Bowman's capsule.

DOI ID

10.1074/jbc.c000127200